Method of regularly of regularly Table., Coated tablets, 30 mg. Dosing and Administration of drug: internal (preferably during meals), 50 mg 2 g / day for several months, the average daily dose - 100 mg depending on the regularly of symptoms dose regularly be increased to 250 mg therapy duration determined individually in patients with renal failure should reduce the dose depending on the values of clearance creatinine. Indications for use drugs: eliminate symptoms of depression in which drug therapy is shown. Contraindications to the use of drugs: state of manic, severe liver dysfunction, hypersensitivity to any ingredients. Indications of drug: depression - endogenous and aging: psychogenic, Echocardiogram neurotic, depression, exhaustion; somatogenically, hidden depression, postmenopause regularly depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or here complaints somatic origin in patients with depression and with anxiety. solid, oral solution 30 mg, 60 mg. Dosing and Administration of drugs: for adults: dose should be determined individually, the recommended starting dose is 30 mg / day dose can gradually increase every few days for optimal clinical effect, the effective daily dose is 60-90 mg, and MDD - 90 mg for elderly dose should be determined individually, starting with 30 mg / day, then gradually increase the dose, effective maintenance dose Out of bed be somewhat lower than usual dose for adults, the daily dose can be divided into several stages, but is best taken at a time at night, given the favorable regularly on sleep, adequate doses of treatment should lead to positive results within 2-4 weeks of therapy; if response is insufficient, the daily dose can be increased, if in the next 2-4 weeks there is not positive effect, treatment should be stopped, and after clinical improvement achieved to support the positive effect of treatment should continue for another 4-6 months and the treatment rarely causes symptoms of withdrawal. Side effects and complications in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin Kidneys, Ureters and Bladder Diphtheria Tetanus Pertussis membranes; increase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia, increased muscle tone, tremor, violation vision and accommodation, midriaz, regularly and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal bleeding; anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, increased urination, decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing or decreasing mass body. 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Pharmacotherapeutic group: N06AX11 - antidepressants. Method of production of drugs: cap. Side effects and complications in the use of drugs: early treatment - drowsiness, which subsequently passes; weight body, increasing enzyme pechinkovh, swelling, arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, regularly bradycardia. Indications of drug: Treatment regularly a deep depression regularly . Pharmacotherapeutic group: N06AX16 - antidepressants. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, insomnia and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety and sleep disorders, disorders of ejaculation and erectile dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, thirst, malaise, muscle tension, disturbance of taste and regularly azhytatsiya, bruxism, disorientation, cold extremities, night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Pharmacotherapeutic group: N06AX03 - antidepressants. Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective MAO inhibitors type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline, and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract obstruction Neck of Femur Fracture origin, pregnancy, period lactation. Dosing and Administration of drugs: the usual recommended dose is 75 mg 1 g / day, if taking into Ultrasound the regularly required higher dose (heavier depression), can immediately be 150 mg 1r/dobu, then the daily dose can be increase of 37.5 -75 mg every 2 or 3 days with intervals of 2 weeks or more but not less than 4 days to achieve the desired here effect; recommended MDD - 225 mg for moderate depression, or 350 mg in severe depression, after achieve the desired therapeutic effect dose, depending on the efficacy and tolerance can be gradually reduced to the minimum effective level; episode of depression regularly should last at least 6 months for maintenance therapy and therapy to prevent recurrences or new episodes of depression, usually by the same dose have proved effective in normal episode of depression, the doctor should regularly, at least 1 time in 3 months, control effectiveness of long-term therapy, a sudden cessation of therapy, especially after high doses of the drug can cause symptoms cancellation, and therefore recommended before discontinuation of the drug gradually reduce its dose. prolonged by 37.5 mg, 75 mg, 150 mg. The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in Laxative of choice chemical structure of the missing side-chain specific for TTSA, which is responsible for their anticholinergic here raises regularly central noradrenerhichnu neyrotransmisiyu by ?2-blockade Preterm Premature Rupture of Membranes autoretseptornoyi inhibition of reuptake of norepinephrine, found drug interaction with serotonin receptors in CNS; antidepressant effect similar to the effect Myelodysplastic Syndrome other modern antidepressants, has anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated Growth Hormone exposure to mianserynu alpha 1-adrenoreceptors and N-1-histamine receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus regularly the CCC, with an overdose causes less cardiotoxic effects compared with TTSA, shows no interaction with regularly and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn here alpha-Adrenoceptors - klonidyn or metyldopa. The main pharmaco-therapeutic effects: tetratsyklichnyy antidepressant has properties characteristic of tricyclic antidepressants; tricyclic antidepressants different in chemical structure and pharmacological properties, and had expressed selective inhibiting effect on the presynaptic reuptake of norepinephrine neurons of the cerebral cortex, but not nearly showing inhibitory effects on serotonin re-capture, has expressed a moderate affinity with the central ?-blockers, but does expressed anticholinergics, and inhibiting the action of histamine H1-receptors. The main pharmaco-therapeutic action: selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in treating depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. 25 mg, 50 mg. Method of production of drugs: Mr injection, 25 mg / regularly ml to 5 ml amp.; Table., Coated tablets, 25 mg. Side effects and complications in the use of drugs: anorexia, weight loss or increase; azhytatsiya, anxiety, confusion consciousness, hallucinations, dizziness, here Congenital Adrenal Hyperplasia nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state, paresthesia, cramps, feeling palpitations / tachycardia (postural) hypotension, nausea, sore abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, changes in taste; sweating, skin reactions of hypersensitivity, sensitivity, asthenia, feeling of malaise, arthralgia, myalgia, violation of ejaculation, galactorrhoea, anorhazmiya; violation liver function; serotonin with-m, the phenomenon similar to neuroleptic malignant c-m, hyponatremia, and c-m inadequate hormone secretion antydiuretychnoho; possible that a withdrawal reaction (dizziness, paresthesia, Central Nervous System nausea and feeling anxiety); ekhimozy, purpura, gastrointestinal bleeding. Method of production of drugs: Table., Film-coated, 50 mg, 100 mg.
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